Cross-talking between microbiota and complex mucosal systems: study of interaction models between PAMPs/PRRS and mitochondria
The research, starting from most elementary and innate antigenic recognition mechanisms, aims to understand the interaction created between the microbial component colonizing various mucosae (with particular regard to the gastrointestinal tract) and the mucosal barrier homeostasis. In particular, we want to understand whether fragments of bacterial genomic material (small-RNA), until now neglected because difficult to identify and interpret, have a role in mitochondrial receptor stimulation, initiating a process of cellular energetic re-modulation that leads to functional barrier deficits. The goal of this topic is to find elementary interaction strategies between bacteria and organs, in order to restore them during the pathology.
Keywords - ENGLISH
microbioma, small-rna, mucosal system, mitochondria, pathology
Active participants in the research line (PI last author or *)
Gavazza Alessandra; Cerquetella Matteo; Lucia Biagini; Danilo de Bellis; Rossi Giacomo.
External Collaborations
University of Veterinary Medicine Vienna - Veterinärplatz; TexasandAM – GI Lab; Politecnica delle Marche – Biology; Iowa state University – Vet. Med.; San Raffaele- Humanitas – Milano.
Pillar
Animal Health
Macroareas in Animal Health
Biological processes
Email Address
giacomo.rossi@unicam.it
Link to Relevant Publications