Potential diagnostic and therapeutic role of extracellular vesicles in small animal reproduction
Intercellular communication is an essential process for multicellular organisms and their relationship with the host and external environment. A new mechanism has recently been in the spotlight for cellular communication: the release of membrane-enclosed compartments, most called extracellular vesicles (EVs). Extracellular vesicles (EVs) are small biological particles surrounded by a membrane with an unusual lipid composition and a striking cholesterol/phospholipidic ratio.
Extracellular vesicles have garnered significant attention as critical mediators of intercellular communication in human and mammalian biological processes, regarding to reproductive aspects.
In mammals, extracellular vesicles have been isolated from a wide variety of biological fluids, and regarding to reproductive organs from amniotic fluid, seminal fluid, follicular and oviductal fluid and uterine contents, from embryonic and placental tissues.
Extracellular vesicles have been proven to influence many processes in both male and female reproductive systems, including acrosomal reaction, sperm capacitation and maturation, gametogenesis, and embryo implantation in the endometrium during pregnancy
Understanding the specific mechanisms and factors involved in reproduction of small animals, especially those related to the immune system, is crucial for advancing reproductive science and veterinary medicine and could allow for the development of interventions to address fertility issues and ensure successful reproduction in small animal
Keywords - ENGLISH
extracellular vesicles, reproduction, fertility, small animal
Active participants in the research line (PI last author or *)
Sara Pastore, Angela Polisca, RIta Romani, Ilaria Bellezza , Alessandro Troisi
Pillar
Animal Health
Macroareas in Animal Health
Diagnostic and therapeutic
Email Address
alessandro.troisi@unicam.it
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