Human Genomics: Complex Traits and Personalized Medicine
This abstract outline the laboratory activities undertaken in the realm of Human Genomics, specifically focusing on the investigation of complex traits and the development of strategies for personalized medicine. The research endeavors involve employing state-of-the-art genomic technologies, including high-throughput sequencing and advanced bioinformatics analyses, to decipher the intricate genetic landscape governing complex traits within the human genome.
In our laboratory, the primary objective is to identify and characterize genetic markers associated with diverse complex traits, ranging from disease susceptibility to individual responses to therapeutic interventions. Rigorous experimentation, integrated with cutting-edge computational approaches, facilitates the extraction of meaningful insights from large-scale genomic datasets. The emphasis lies in unraveling the genetic determinants contributing to the complexity of human phenotypes, ultimately providing a foundation for precision medicine.
Furthermore, our investigations extend to the translation of genomic discoveries into personalized therapeutic approaches. By delineating individual genetic profiles, we aim to contribute to the realization of tailored medical interventions, optimizing treatment outcomes and minimizing adverse effects. This abstract encapsulates the ongoing laboratory activities, highlighting their significance in advancing our understanding of human genomics and paving the way for a more personalized and effective approach to medical care.
Keywords - ENGLISH
Bioinformatics; Complex Traits; Computational Biology; Genomics; Genomic Epidemiology; Next-Generation Sequencing
Active participants in the research line (PI last author or *)
Giovanni Deiana; Stefano Pallotti; Benedetta Torbidoni-Baldassari; Valerio Napolioni
External Collaborations
Prof. Serena Dato, Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy; Prof. Michael D. Greicius, Stanford University School of Medicine, Stanford, USA; Prof. Jie Huang, School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China; Prof. Patrizia Mecocci, University of Perugia, School of Medicine, Perugia, Italy; Prof. Luigina Romani, University San Raffaele and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele, Milan, Italy.
Pillar
Human Health
Macroareas in Human Health
Biology of health and disease
Relevant research grants (national/international) funding specifically this Research Line
PRIN: PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE – Bando 2022, EXTREMAL: EXTREMe phenotypes for Aging and Longevity; ANALISI PRS DA SHALLOW – Polo GGB, Siena, Italy.
Email Address
valerio.napolioni@unicam.it
Link to Relevant Publications