Non-transfusional hemo-components for tissue repair and regeneration: a modern, topical, therapeutic approach
Hemo-components for non transfusional use are "therapeutic blood constituents that can be prepared using simple physical means aimed at obtaining their separation" (DM 3-3-2005). To facilitate the healing of damaged tissues, various techniques can be used to place hemo-components on the site of injury. Among the hemo-components, various platelet concentrates can be mentioned, including platelet-rich plasma (PRP), platelet gel, platelet-rich fibrin (PRF). This innovative therapeutic approach of regenerative medicine is constantly evolving, as attested by the growing number of studies published on the topic.
The main purpose of the research line is to increase knowledge on the mechanism of action and effectiveness of non transfusional hemo-components, identifying their main therapeutic indications and evaluating their effect both in vitro and in vivo in animals.
Appropriate meta-analyses are contributing to the definition of the research line, which delves into aspects of high translational value. Studies are being carried out regarding the development of production techniques, the characterization of fresh and preserved hemo-components (cytological, biochemical, rheological, microbiological evaluations), the in vitro effect (on cell cultures, on bacteria and fungi, on seminal fluid), the in vivo effect on various types of tissue lesions and involving different body areas, the synergistic action with other therapeutic systems.
Keywords - ENGLISH
platelets, growth factors, regenerative medicine, tissue injuries, reconstructive surgery, meta-analysis
Active participants in the research line (PI last author or *)
Giulia Bonacucina, Marco Cespi, Silvia Vincenzetti, Anna-Rita Attili, Massimo Bramucci, Luana Quassinti, Evelina Serri, Angela Palumbo Piccionello, Alessandro Troisi, Adolfo Maria Tambella (PI)
External Collaborations
Progetto Re.Me.Di.U.M.-Bio.Pro: Carmen Mortellaro (Unicamillus Roma), Anna Tampieri (CNR-ISSMC Faenza), Massimo Del Fabbro (Università di Milano IRCCS Galeazzi Milano), Antonio Scarano (Università di Chieti), Adolfo Maria Tambella (Università di Camerino), Maurizio Giacomello (Università di Milano-Bicocca), Simone Sprio (CNR-ISSMC Faenza)
Pillar
Animal Health
Macroareas in Animal Health
Diagnostic and therapeutic
Relevant research grants (national/international) funding specifically this Research Line
Fondo FAR (Fondo di Ateneo per la Ricerca) dell’Università di Camerino
Email Address
adolfomaria.tambella@unicam.it
Link to Relevant Publications