First 1000 days of life gut microbiota: early probiotic supplementation for a healthy neurodevelopment.
The research aims to study the role of gut-brain axis during the first years of human life. The studies are focusing on the correlation within a healthy neurodevelopment in child and the potential activity of specific probiotic strains used during pregnancy and/or in the very early days of life as valuable mean for a healthy infant brain development. The probiotic supplementation will be also studied as prevention approach in specific neurodevelopment disorders. The research address various aspects related to brain inflammatory state and its relationship with gut microbiota with several in vitro approaches using a fermentation system mimicking the microbial fermentation in human gut and organs-on-a-chip system, device containing organ-specific cells which are cultured and organized to mimic the physiological and mechanical properties of target organs.
Keywords - ENGLISH
gut microbiota; child; probiotics; postbiotics; gut-brain axis; neuroinflammation
Active participants in the research line (PI last author or *)
Lucia Occhigrossi, Maria Magdalena Coman, Stefania Silvi
External Collaborations
Synbiotec Srl
Pillar
Human Health
Macroareas in Human Health
Healthy and pathogenic microorganisms
Relevant research grants (national/international) funding specifically this Research Line
Project funded under DM 117/2023
Email Address
stefania.silvi@unicam.it
Link to Relevant Publications