Investigating cellular pathways in cancer to understand cancer biology and search for new therapeutic targets.
The research interest is mainly focused on the study of molecular mechanisms influencing cell fate during cancer progression and treatment. Although we have greatly increased our knowledge of the signals that regulate and guide tumor progression, the controlling cancer growth still remains an open challenge. In fact, cancer cells, especially cancer stem cells, acquire the ability to modulate and/or impair several cellular pathways such as autophagy, apoptosis, mitophagy, metabolic adaptations, bi-directional communication between organelles, ion channel activity to promote relapse and therapy resistance.
Keywords - ENGLISH
cancer, autophay, mitophagy, calcium flux, ion channels, chemoresistance
Active participants in the research line (PI last author or *)
Consuelo Amantini
Pillar
Human Health
Macroareas in Human Health
Biology of health and disease
Email Address
consuelo.amantini@unicam.it
Link to Relevant Publications